Includes bibliographical references and index.

Clinical, physiology and genetics changes in heart failure -- Introduction to heart failure -- Cardiac function in heart failure: the role of calcium cycling -- Gene profiling of the failing heart: epigenetics -- Biochemical and molecular changes in heart failure -- Bioenergetics and metabolic changes in the failing heart -- Mitochondrial organelle and the heart -- Multidimensional role of mitochondria in heart failure -- Experimental models of heart failure -- Animal models of heart failure -- Signaling, stress and cellular changes in heart failure -- Signaling cascades in heart failure: from cardiomyocytes growth and survival to mitochondrial signaling pathways -- Cyclic nucleotides signaling (second messengers) and control of myocardial function: effects of heart failure -- Calcium signaling: receptors, effectors, and other signaling pathways -- Oxidative stress and heart failure -- Cardiac remodeling and cell death in heart failure -- Peripheral changes and co-morbid conditions in heart failure -- Heart failure and changes at the periphery: vascular, inflammation, neurohormonal, and renal systems -- Comorbidities in heart failure -- Heart failure in children -- Mechanisms and clinical recognition and management of heart failure in infants and children -- Mechanical circulatory support and heart transplantation in children with severe refractory heart failure -- Aging and the failing heart -- Basic mechanisms mediating cardiomyopathy and heart failure in aging -- Heart failure of aging: clinical considerations -- Diagnostic methodology in heart failure -- Diagnosis of heart failure: evidence-based perspective -- Omics application in heart failure: novel diagnostic and prognostic markers to understand pathophysiology and find new therapies -- Available and forthcoming therapies for heart failure -- Treatment of chronic heart failure -- Gene therapy in heart failure: forthcoming therapies -- Myocardial cell-based regeneration in heart failure -- Looking to the future -- Future frontiers in heart failure.

Also issued online.