Natural products targeting clinically relevant enzymes

by Andrade, Paula B.,
[ book - latin ] Physical details: xvii, 329 pages : illustrations ; 25 cm ISBN:9783527342051 (print ISBN). Item type: book - latin
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Current location Call number Copy number Status Date due Barcode
دانشکده داروسازی
QV 736 A553n 2017 (Browse shelf) 2017 Available 8000008272

Includes bibliographical references and index.

Natural products as enzyme inhibitors -- Molecular targets of clinically relevant natural products from filamentous marine cyanobacteria -- Natural angiotensin converting enzyme (ACE) inhibitors with antihypertensive properties -- Phospholipase A2 inhibitors of marine origin -- Beta-secretase (BACE1) inhibitors from natural products -- Hypoglycaemic effects of plants food constituents via inhibition of carbohydrate-hydrolysing enzymes: from chemistry to future applications -- Natural products targeting clinically relevant enzymes of eicosanoid biosynthesis implicated in inflammation and cancer -- Anti-HIV natural products -- Natural inhibitors of mitochondrial respiratory chain: therapeutic and toxicological implications -- Targeting enzymatic pathways with marine-derived clinical agents -- Anti-malarial drug discovery: new enzyme inhibitors -- Natural plant-derived acetylcholinesterase inhibitors: relevance for Alzheimer's disease.

The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

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