On framing the research question and choosing the appropriate research design / Patrick Parfrey and Pietro Ravani -- Longitudinal studies and determination of risk / Sean W. Murphy -- Modeling longitudinal data, I : principles of multivariate analysis / Pietro Ravani, Brendan Barrett, and Patrick Parfrey -- Modeling longitudinal data, II : standard regression models and extensions / Pietro Ravani, Brendan Barrett, and Patrick Parfrey -- The design of randomized controlled trials / Bryan M. Curtis, Brendan J. Barrett, and Patrick Parfrey -- Analysis of randomized controlled clinical trials / Robert N. Foley -- Evaluation of diagnostic tests / John M. Fardy -- Biomarkers and surrogates in clinical studies / Claudio Rigatto andd Brendan J. Barrett -- Measurement and analysis of patient-reported outcomes / Klemens B. Meyer and Kimberly A. Clayton -- Bias in clinical studies of genetic diseases / Susan Stuckless and Patrick Parfrey -- Genetic epidemiology of complex phenotypes / Lynette Peddle and Proton Rahman.

Qualitative research in clinical epidemiology / Deborah M. Gregory and Christine Y. Way -- Primer on systematic review and meta-analysis / Marcello Tonelli, Dan Hackman, and Amit X. Garg -- The role of health economics within clinical research / Braden J. Manns -- Development and limitations of clinical practice guidelines / Bruce Culleton -- Basics of health technology assessment / Daria O'Reilly, Kaitryn Campbell, and Ron Goeree -- Research ethics for clinical researchers / John D. Harnett and Richard Neumann -- Budgeting, funding, and managing clinical research projects / Elizabeth Hatfield, Elizabeth Dicks, and Patrick Parfrey.